In northeastern Congo, more than 600 people have fallen ill with the Ebola
virus, and at least 368 people have died from the disease. It’s been difficult
to contain the virus because of conflict in the region, despite medical
advances, including a vaccine.
The Democratic Republic of Congo is where Ebola was first discovered in 1976
when the country was called Zaire. The disease was named after the Ebola River
where the virus was spreading. Between then and 2013, there was no treatment or
a vaccine. The outbreak ran its course in quarantined communities.
Scientists started studying the virus, however, trying to come up with
better ways to handle its various deadly strains. They succeeded in producing a
vaccine to help end the Ebola epidemic that swept through three West African
countries between 2013 and 2016. More than 11,000 people died in that outbreak.
At that time, treatment for the Zaire strain of Ebola was developed. It was
costly to produce and didn’t work on two other lethal strains, the Sudan and
But now scientists have found one. Their research produced a drug cocktail
called MBP134 that helped monkeys infected with three deadly strains of Ebola
recover from the disease.
What’s more, the treatment requires a single intravenous injection.
Thomas Geisbert, Ph.D., led the research
at the University of Texas Medical Branch, part of a public-private
partnership that also included Mapp Biopharmaceuticals, the U.S. Army Research
Institute of Infectious Diseases, and the Public Health Agency of Canada.
In an interview with VOA, Geisbert stressed the need for a treatment that
would be effective against all strains of Ebola.
“When an outbreak occurs, we really don’t know which one of those three
strains, species, we call them, is the cause of that particular episode,”
He added that the treatments available have been effective only against the
Zaire species, which leaves people infected with the other species unprotected.
“Our goal was to develop a treatment that would work regardless of the
particular strain of Ebola that was causing it,” Geisbert said.
“If I have to make a drug that only works against Zaire, and another drug
that only works against Sudan and another drug that only works against the
Bundibugyo species, that is extremely expensive,” he added.
Geisbert said the treatment will save valuable time in determining which
strain of Ebola is circulating in a particular outbreak. It will save lives
because people can be treated immediately, and it will also save money.
There’s no profit for the pharmaceutical companies that produce the drugs.
“It’s not like you’re making up vaccine for flu where companies [are] going
to make a profit. There’s really a small global market for Ebola so it really
has to be sponsored by the government,” he said.
In addition to the U.S. Army and the Canadian government, the U.S. National
Institutes of Health has supported much of this research.
Geisbert said the work ahead involves tweaking the dose to its lowest
possible amount, making it easier to distribute — again to reduce costs — and
conducting clinical trials in humans to ensure the treatment is safe and
Geisbert is confident it will work in humans, although he cautioned that in
science, nothing is certain.